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9-Day American Cruise Line Ohio River Cruise

Louisville, KY to Pittsburgh, PA: All-Inclusive River Cruises

This brand new 9-day voyage is a celebration of America’s heartland, inviting you to experience the remarkable history and natural beauty that graces the banks of the iconic Ohio River.

Revel in the excitement of the Kentucky Derby at Churchill Downs and explore the rich bourbon heritage of Louisville with a visit to one of its famed distilleries. Experience Madison, boasting one of the largest National Historic Landmark Districts in the country. Journey to the vibrant riverfront city of Cincinnati boasting world-class museums and the first professional baseball team in the U.S.

Spend a day cruising the Ohio River, where gentle currents and diverse landscapes make for a relaxing and picturesque adventure. Travel to Marietta, the first permanent settlement in the Northwest Territory, and a testament to America’s early frontier days. Conclude your journey in “Steel City” Pittsburgh where you can admire its stunning skyline punctuated by iconic bridges.

“I book American Cruise Lines often, and my solo female travelers absolutely love it,” said Michele Peleras, a travel advisor at Cruise & Travel Experts. “Between the personalized, friendly service, excellent food, small-ship atmosphere, spacious cabins, and favorable single supplement pricing, it’s a standout option. Plus, the unique itineraries make it a perfect fit for my older clients who prefer to explore without traveling too far from home.”

“I have several wonderful clients who have enjoyed multiple cruises with American Cruise Lines,” said Vickie Grysen, another travel advisor at Cruise & Travel Experts. “They started with a Snake River cruise in the Pacific Northwest and recently experienced the Puget Sound itinerary. They returned raving about the staff’s kindness and attentiveness—how they consistently went the extra mile to make their journey special. They also loved the well-planned, included local excursions and found the cabins to be spacious and comfortable, great for relaxing after a day of exploration.”

Hear from our Travel Advisors, Michele and Vickie

Save up to $1,000 + Complimentary Airfare on select Ohio River Cruises and Northwest National Parks cruises when you book by May 31, 2026 OR Save up to $2,000 + Complimentary Airfare on select New England Explorer Cruises when you book by May 31, 2026*  Plus receive our exclusive extra of $100 Onboard Credit.

Ship: American Heritage Paddlewheeler | Cruise Line: American Cruise Line | Sail Date: July 31, 2026 | From/To: Louisville, KY to Pittsburgh, PA | Length: 9-Days

Standard Balcony Stateroom From

$4,775

Per person

Deluxe Balcony 2 From

$4,990

Per person

Deluxe Balcony 1 From

$5,310

Per person

Premium Balcony From

$5,655

Per person

*Prices are in USD, per person based on double occupancy, availability and subject to change without notice. All cruise taxes, fees and port expenses are included in the pricing. All promotions are capacity controlled by American Cruise Line and can be eliminated at any time without notice. Exclusive shipboard credit is based on double occupancy. Other restrictions may apply. Ships’ registry: U.S.A.